Gaetano Montelione

Gaetano T. Montelione. American Biophysical Chemist. My primary expertise is in protein biochemistry and NMR spectroscopy. I studied experimental and theoretical physical chemistry at Cornell University, and completed my Ph.D. thesis under the joint supervision of Prof. H. A. Scheraga and Prof. K. Wüthrich. With Prof. G. Wagner I carried out work in NMR pulse sequence development, including the design and implementation of the first triple-resonance protein NMR experiments. The particular strength of our laboratory has been the development of computational NMR methods and software for analysis of protein structures and dynamics. I have also directed a few dozen X-ray crystallography projects, and several integrative projects combining NMR, crystallography, SAXS, and molecular modeling. As Director of the Northeast Structural Genomics Consortium (NESG) for 16 years (2000 – 2016), I also have experience in development of software and databases for structural biology, and in creating a successful high-throughput pipeline for protein sample and structure production. The NESG program involved extensive efforts in new technology development for protein sample production, NMR, X-ray crystallography, and structural bioinformatics, and resulted in more than 350 peer reviewed publications. More than 1,300 3D structures have been determined by our team using both crystallography and NMR methods. I have extensive knowledge of protein biochemistry and protein expression in E. coli, pichia yeast, and HEK293 mammalian expression systems, and in the production of membrane proteins. In order to organize the collaborative efforts of more than 12 research groups and mote than 150 scientists who participated in the NESG program over 16 years, I have lead the development of the NESG Protein Structure Production Platform and the SPiNE LIMS system. I am also a member of several international advisory groups developing ontologies for structural biology, and co-chair of the international wwPDB Task Force on NMR Structure Validation.