Breakout Sessions Salon F
Tuesday September 17th | Washington Marriott
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Legal Interoperability – 09:00 – 12:15
COORDINATORS: Paul F. Uhlir, Enrique Alonso García
9:00 Welcoming remarks and introductions - Paul Uhlir, NAS, US
9:15 Review of white paper on legal interoperability of data and annotated bibliography - Paul Uhlir, NAS, US
9:45 Interest Group website , Natalia Manola, U. Athens, GR
10:00 Workshop plans, Paul Uhlir
10:30 Selection and assessment criteria for case studies, Enrique Alonso, Gov. of Spain & Bob Chen, Columbia U., US
11:30 Instructional materials, Enrique Alonso
11:45 Other issues for consideration by the group, Paul Uhlir
12:00 Summary of actions, Anita Eisenstadt
12:10 Closing remarks, Paul Uhlir
12:15 Meeting adjourns
Toxicogenomics Interoperability – 12:15 – 13:15
COORDINATORS: Diana Hendrickx, Rebecca Boyles
The objective of the Toxicogenomics Interoperability Interest Group is to define opportunities toward enhancing interoperability of existing toxicogenomics databases. Toxicogenomics is the application of genomic technology to study the impact that chemical exposures may have on public health. Historically chemical toxicity assessment has relied on time-consuming and costly animal exposure experiments. Toxicogenomics-based cellular models have been proposed and adopted as an alternative to animal testing, resulting in a rapid increase in these data, and associated databases. Meaningfully applying this data to understand the potential chemical effects on human toxicity pathways is a particular challenge facing the public health community. Application of the data requires that the data be accessible and interoperable for scientists to interrogate. Several large databases have been identified during the joint US – European Union “Workshop on Identifying Opportunities for Global Integration of Toxicogenomics Databases” held at the National Institute for Environmental Health Sciences in Durham, North Carolina, USA on June 26 and 27, 2013. During this event there was general agreement among database owners to engage in a collaborative process toward interoperability, which led to the creation of an RDA interest group. To guide the direction of any future database interoperability efforts, user stories have been solicited from existing stakeholder groups via an e-questionnaire focused on soliciting user stories and data limitations from the scientific community. In this session, the importance of toxicogenomic data within the context of public health, as well as the analysis of the collected user stories will be used to produce a number of use cases and other requirements of a roadmap toward interoperability will be presented and discussed.
Big Data Analytics – 14:00 – 16:00
COORDINATORS: Morris Riedel, Rahul Ramachandran
This is the second BoF and a follow on from the first BoF that has been held at the 1st RDA Plenary in Gothenburg, Sweden.
The BoF will review the developments since the first BoF both in attendees' organisations and in international bodies dealing with the standards and policy development in the area of Big Data and Data Intensive Science and technologies. The BoF will provide an overview of the Big Data Architecture Framework that incorporates the main components of the Big Data Ecosystem and discuss how it can be used for defining the stakeholder model, skills profile and curriculum scope.
The BoF will discuss the prospective Interest Group charter possible cooperation framework for inter-organisational cooperation in developing educational and training programs on Data Intensive Science and e-Infrastructure.
BoF: Chemical Safety – 16:15 - 17:15
COORDINATOR: Diana Hendrickx
The aim of establishing a working group for chemical safety is to enhance data sharing, access, and analysis capabilities with a focus on existing toxicogenomics data. Alternatives to animal testing and adoption of rapid assay methods have expanded in the last decade driven by the need to identify hazards and prioritize testing for an increasing number of environmental chemicals as described in the Toxicity Testing in the 21st Century report by NRC in 2007 and the requirements of the EU REACH regulations. It is this context that genomic technologies are being applied to study the impact that chemical exposures may have on public health, referred to here as toxicogenomics. Rapid deployment of these technologies has created an influx of toxicogenomic research data and related databases. Meaningful application of these data to understand the potential chemical effects on human toxicity pathways is a particular challenge facing the public health community. Extrapolation of the existing data from in vitro results to an in vivo system, to untested chemical space, and expanding the knowledge of toxicity pathways is being undertaken by a broad based research community consisting of statisticians, data scientists, toxicologists, genomics experts, and others. The chemical safety working group proposes to contribute to the larger chemical safety effort by beginning to address the obstacles related to sharing of toxicogenomic data held within existing databases. In the Toxicogenomics Interoperability interest group, we conducted an e-questionnaire on data uses and limitations within the community. The goal of this e-questionnaire was to better understand how the data are currently being used in the field, so that a roadmap towards database interoperability would be grounded in the current work and needs of ongoing toxicogenomic and chemical safety research. In this session, we will discuss current and future steps to integrate the results of the e-questionnaire into a case statement for an RDA chemical safety working group.
Education and Training in Data Intensive Science – 17:15 – 18:15
COORDINATOR: Yuri Demchenko