Plenary 3 - Toxicogenomics session

The objective of the Toxicogenomics Interoperability Interest Group is to define opportunities toward enhancing interoperability of existing toxicogenomics databases. Toxicogenomics is the application of genomic technology to study the impact that chemical exposures may have on public health. Historically chemical toxicity assessment has relied on time-consuming and costly animal exposure experiments. Toxicogenomics-based cellular models have been proposed and adopted as an alternative to animal testing, resulting in a rapid increase in these data, and associated databases. Meaningfully applying this data to understand the potential chemical effects on human toxicity pathways is a particular challenge facing the public health community. Application of the data requires that the data be accessible and interoperable for scientists to interrogate. Several large databases have been identified during the joint US – European Union “Workshop on Identifying Opportunities for Global Integration of Toxicogenomics Databases” held at the National Institute for Environmental Health Sciences in Durham, North Carolina, USA on June 26 and 27, 2013. During this event there was general agreement among database owners to engage in a collaborative process toward interoperability, which led to the creation of an RDA interest group. To guide the direction of any future database interoperability efforts, user stories and data limitations have been solicited from existing stakeholder groups via an e-questionnaire. The results of this survey were discussed on our first RDA session at RDA 2^nd plenary.

This is the second RDA session and a follow up on the first session that has been held at RDA 2^nd Plenary in Washington DC, USA.

The session will review the progress of the group since RDA 2^nd plenary, discuss new collaborations and our plans to define and implement a use case of toxicogenomics interoperability.

Links to additional reading material:

Group web page:

https://www.rd-alliance.org/group/toxicogenomics-interoperability-ig.html

Toxicogenomics Interoperability IG Charter:

https://www.rd-alliance.org/filedepot?cid=132&fid=138

Sheets, poster and summary previous RDA session (RDA 2^nd plenary):

https://rd-alliance.org/filedepot/folder/147

Agenda

Time (Dublin)	Time (Phoenix)
15:30	8:30	Welcome
15:35	8:35	Introduction for newcomers in the Toxicogenomics Interoperability IG
15:50	8:50	Summary outcome Breakout session RDA 2^nd plenary
16:05	9:05	Summary of progress since RDA 2^nd plenary
16:20	9:20	Discussion: Use case + implementation
16:50	9:50	Closing remarks