Multi-Omics Metadata Standards Integration (MOMSI) WG
Background
Multi-omics data integration merges multiple Omics data types (e.g., genomics, proteomics, metabolomics, phenomics, etc.) leveraging a wide range of high-throughput technologies (sequencing, mass spectrometry, imaging, etc.) for quantification and characterization of large complex pools of biological molecules. Multi-omics data integration and analysis provides a closer look into the complex structural and functional interactions at the molecular level for improving our understanding of biological dynamics of living organism(s) across the life science landscape.
As significant advancements in Omics instrument technologies continue to evolve as does the volume of subject matter expert experimental methodologies. As a result, there has been an unprecedented increase in the generation and storage of multi-omics data over the past decade. Despite many challenges remain regarding multi-omics data management and sharing for reuse of complex Omics datasets (Figure 1).
Figure 1. Challenges of effectively managing and integrating multi-omics data identified during the RDA-OfR WG brainstorming workshop in September 2023.
A persistent challenge is the vast array of fragmented experimental metadata and data formats generated across the different Omics domains, making it difficult to manage and integrate multi-omics data prior to downstream analyses.
📦 MOMSI Deliverables & Upcoming Activities
✅ = Complete; 📮 = Under Community Review; 🛠️ = Ongoing or In Development; 👀 = Upcoming
1. Omics Landscape Review and Evaluation of Existing Community Standards – Explore Deliverable 1a (Continuous Curation) ✅📮
The MOMSI WG Landscape Review Dashboard is both a community-driven curation workflow repository and interactive web-based dashboard tool. Explore >250 standards containing various Multi-omics domain (genomics, proteomics, metabolomics, lipidomics, etc.) and universal (generalist and subject agnostic) standards curated by the MOMSI WG. Curated standards include controlled vocabularies/ontologies, metadata reporting guidelines, data models/formats, and identifier schemas relevant to Omics application technologies and FAIR best practices. The MOMSI WG Landscape Review Dashboard is designed to support continuous curation of Omics domain and generalist community-accepted standards in real time aiding next-generation Multi-Omics data integration platform system developments, refinements, and new implementations. See Contributing to learn more.
2. Multi-Omics Standards Collection at FAIRsharing – Explore Deliverable 1b (Advanced Search & Filtered Selection) 🛠️
Leveraging and building upon existing resource records at FAIRsharing (in collaboration with the FAIRsharing Registry RDA WG), the MOMSI WG Collection (Deliverable 1b) provides a live recommended list of expert-reviewed domain and generalist standards aimed at enhancing “state-of-the-art” developments in Multi-omics data harmonization and integration. Standards included in this collection focus on Omics relevant terminologies, metadata reporting guidelines, data models/formats, and identifier schemas. New and existing standards listed in this collection have undergone an iterative in-depth landscape review process using the MOMSI curation dashboard sustainability workflow located at our MOMSI GitHub repository (Deliverable 1a). This process involves evaluating the accuracy and completeness of each standard and the minimal information criteria required for curation prior to addition to this collection. Our collection seeks to benefit and encourage continuous, open, and expert-driven curation of machine-actionable Multi-omics community standards. This collection is designed to support continuous Multi-omics community standard curation in keeping pace with evolving research data management tasks, roles, and research data sharing best practices.
*NOTE* – Please refer to our contributing curation guidelines prior to making any edits to this collection, as this process requires a formal issue request submission.
3. Multi-Omics Standards Integration Gap Analysis (Deliverable 2a) – Upcoming 👀
There are currently many well-established and well-developed Omics standards, but knowing intuitively or immediately which standards are complementary across domains is not obvious. Leveraging the work from previous deliverables, this WG will provide a gap analysis that will identify common data standards and metadata reporting guidelines implemented across Omics domains to link complementary integration points. This activity aims to support common metadata elements outlined in our resulting FAIRsharing standards collection for downstream data integration endeavors. This analysis will highlight current domain metadata standard reporting gaps and reveal new synergistic collaborations for Multi-omics standard community implementation developments where applicable.
4. Multi-omics FAIRsharing Database Use-case Collection (Deliverable 2b) – Pending
MOMSI Multi-omics data and metadata integration use-case records at FAIRsharing, identified during the gap analysis, to be included in as a new “Collection” consisting of multi-omics databases, repositories, and/or knowledgebases implementing >2 different Omics domain data standard types from >1 application technology identified as key nodes of integration by the MOMSI WG.
🗓️ Up-to-date MOMSI Meeting Schedule & Quick Links
|
Dates
|
Topic Highlights
|
Documentation Links
|
| 7 September 2023 |
Brainstorming Workshops: Definition of WG Scope |
|
| 29 November 2023 |
1st WG Meeting: Kick-off
- Member consultation and recruitment.
- Omics resources and related training materials overview.
|
|
| 13 December 2023 |
2nd WG Meeting: Deliverable 1a Curation Activities
- Omics domain break-out group assignments (Genomics, Proteomic, Metabolomics, Universal)
- Landscape review and collection of existing Omics community standards.
|
|
| 25 January 2024 |
3rd WG Meeting: Deliverable 1a Curation Activities (continued) |
|
| 21 February 2024 |
4th WG Meeting: Deliverable 1a Curation Activities (continued)
- Assignment of research data lifecycle standards.
- Omics Collection selection criteria discussion.
|
|
| 20 March 2024 |
5th WG Meeting: Deliverable 1a Activities (continued)
- Landscape review completion timeline.
- Deliverable 1a machine-actionable formats discussion.
|
|
| 17 April 2024 |
6th WG Meeting: Deliverable 1b Activities
- FAIRsharing Collection standard selections.
- Discussion on ‘Defining Selection Criteria for Multi-omics Standards’.
|
|
| May 2024 |
RDA’s 22nd Virtual Plenary Meeting (VP22)
|
|
| 12 June 2024 |
7th WG Meeting: RDA VP22 Recap & Discussion
- Deliverables 1a and 1b “Next Steps”.
|
|
| 10 July 2024 |
8th WG Meeting: Invited speaker Allyson Lister
- Presentation on “How FAIRsharing Collections can help RDA WGs?”.
|
|
| 7 August 2024 |
9th WG Meeting: Deliverable 1b Activities (continued)
- Supporting materials documentation for Deliverables 1a and 1b curation workflow.
|
|
| 4 September 2024 |
10th WG Meeting: New Proposal & Scoped Activities
- RDA TIGER support services application in progress to support sustainability workflow.
|
|
| 2 October 2024 |
11th WG Meeting: Proposal Acceptance & Updates
- RDA TIGER “Call for Experts – Technical design and development for the MOMSI Landscape Dashboard”.
|
|
| 30 October 2024 |
12th WG Meeting: Collection Build & Demo Release
|
|
| 27 November 2024 |
RDA’s 23rd Plenary Meeting (P23)
|
|
| 25 December 2024 |
No Meeting: Happy Holidays! |
|
| 22 January 2025 |
13th WG Meeting: RDA TIGER Developments
- “Call for Experts” selection is complete and work has begun.
|
|
| 19 February 2025 |
14th WG Meeting: Dashboard Development Updates |
|
| 26 March 2025 |
15th WG Meeting: Dashboard Feature Highlights |
|
| 7 April 2025 |
RDA’s 24th Virtual Plenary Meeting (VP24)
|
|
| 16 April 2025 |
16th WG Meeting: Dashboard Repository Reveal & Live Demo
|
|
| 14 May 2025 |
17th WG Meeting: Dashboard in Community Review, Upcoming Activities, and IDW 2025
- Upcoming Gap Analysis Activities (final deliverable opportunties).
|
|
| 14 June 2025 |
18th WG Meeting: TBD |
|
| 14 July 2025 |
19th WG Meeting: TBD |
|
| 14 August 2025 |
20th WG Meeting: TBD |
|
| 14 September 2025 |
21st WG Meeting: TBD |
|
| 14 October 2025 |
22nd WG Meeting: TBD |
|
| 14 November 2025 |
23rd WG Meeting: TBD |
|
| December 2025 |
24th WG Meeting: TBD |
|
Note: As of August 2024, this working group’s name has changed to the “Multi-Omics Metadata Standards Integration (MOMSI) WG” and was previously known as the “RDA-OfR Creating a Multi-omics Metadata Schema Standard Reporting Matrix WG”.
The MOMSI WG are continually seeking diverse membership, representative of different countries and continents, with expertise in Omics application technologies areas of mass spectrometry and sequencing. Please reach out if you have a high interest to participate but your time zone does not align with our regularly scheduled meetings.
Multi-Omics Metadata Standards Integration (MOMSI) WG
Background
Multi-omics data integration merges multiple Omics data types (e.g., genomics, proteomics, metabolomics, phenomics, etc.) leveraging a wide range of high-throughput technologies (sequencing, mass spectrometry, imaging, etc.) for quantification and characterization of large complex pools of biological molecules. Multi-omics data integration and analysis provides a closer look into the complex structural and functional interactions at the molecular level for improving our understanding of biological dynamics of living organism(s) across the life science landscape.
As significant advancements in Omics instrument technologies continue to evolve as does the volume of subject matter expert experimental methodologies. As a result, there has been an unprecedented increase in the generation and storage of multi-omics data over the past decade. Despite many challenges remain regarding multi-omics data management and sharing for reuse of complex Omics datasets (Figure 1).
Figure 1. Challenges of effectively managing and integrating multi-omics data identified during the RDA-OfR WG brainstorming workshop in September 2023.
A persistent challenge is the vast array of fragmented experimental metadata and data formats generated across the different Omics domains, making it difficult to manage and integrate multi-omics data prior to downstream analyses.
📦 MOMSI Deliverables & Upcoming Activities
✅ = Complete; 📮 = Under Community Review; 🛠️ = Ongoing or In Development; 👀 = Upcoming
1. Omics Landscape Review and Evaluation of Existing Community Standards – Explore Deliverable 1a (Continuous Curation) ✅📮
The MOMSI WG Landscape Review Dashboard is both a community-driven curation workflow repository and interactive web-based dashboard tool. Explore >250 standards containing various Multi-omics domain (genomics, proteomics, metabolomics, lipidomics, etc.) and universal (generalist and subject agnostic) standards curated by the MOMSI WG. Curated standards include controlled vocabularies/ontologies, metadata reporting guidelines, data models/formats, and identifier schemas relevant to Omics application technologies and FAIR best practices. The MOMSI WG Landscape Review Dashboard is designed to support continuous curation of Omics domain and generalist community-accepted standards in real time aiding next-generation Multi-Omics data integration platform system developments, refinements, and new implementations. See Contributing to learn more.
2. Multi-Omics Standards Collection at FAIRsharing – Explore Deliverable 1b (Advanced Search & Filtered Selection) 🛠️
Leveraging and building upon existing resource records at FAIRsharing (in collaboration with the FAIRsharing Registry RDA WG), the MOMSI WG Collection (Deliverable 1b) provides a live recommended list of expert-reviewed domain and generalist standards aimed at enhancing “state-of-the-art” developments in Multi-omics data harmonization and integration. Standards included in this collection focus on Omics relevant terminologies, metadata reporting guidelines, data models/formats, and identifier schemas. New and existing standards listed in this collection have undergone an iterative in-depth landscape review process using the MOMSI curation dashboard sustainability workflow located at our MOMSI GitHub repository (Deliverable 1a). This process involves evaluating the accuracy and completeness of each standard and the minimal information criteria required for curation prior to addition to this collection. Our collection seeks to benefit and encourage continuous, open, and expert-driven curation of machine-actionable Multi-omics community standards. This collection is designed to support continuous Multi-omics community standard curation in keeping pace with evolving research data management tasks, roles, and research data sharing best practices.
*NOTE* – Please refer to our contributing curation guidelines prior to making any edits to this collection, as this process requires a formal issue request submission.
3. Multi-Omics Standards Integration Gap Analysis (Deliverable 2a) – Upcoming 👀
There are currently many well-established and well-developed Omics standards, but knowing intuitively or immediately which standards are complementary across domains is not obvious. Leveraging the work from previous deliverables, this WG will provide a gap analysis that will identify common data standards and metadata reporting guidelines implemented across Omics domains to link complementary integration points. This activity aims to support common metadata elements outlined in our resulting FAIRsharing standards collection for downstream data integration endeavors. This analysis will highlight current domain metadata standard reporting gaps and reveal new synergistic collaborations for Multi-omics standard community implementation developments where applicable.
4. Multi-omics FAIRsharing Database Use-case Collection (Deliverable 2b) – Pending
MOMSI Multi-omics data and metadata integration use-case records at FAIRsharing, identified during the gap analysis, to be included in as a new “Collection” consisting of multi-omics databases, repositories, and/or knowledgebases implementing >2 different Omics domain data standard types from >1 application technology identified as key nodes of integration by the MOMSI WG.
🗓️ Up-to-date MOMSI Meeting Schedule & Quick Links
|
Dates
|
Topic Highlights
|
Documentation Links
|
| 7 September 2023 |
Brainstorming Workshops: Definition of WG Scope |
|
| 29 November 2023 |
1st WG Meeting: Kick-off
- Member consultation and recruitment.
- Omics resources and related training materials overview.
|
|
| 13 December 2023 |
2nd WG Meeting: Deliverable 1a Curation Activities
- Omics domain break-out group assignments (Genomics, Proteomic, Metabolomics, Universal)
- Landscape review and collection of existing Omics community standards.
|
|
| 25 January 2024 |
3rd WG Meeting: Deliverable 1a Curation Activities (continued) |
|
| 21 February 2024 |
4th WG Meeting: Deliverable 1a Curation Activities (continued)
- Assignment of research data lifecycle standards.
- Omics Collection selection criteria discussion.
|
|
| 20 March 2024 |
5th WG Meeting: Deliverable 1a Activities (continued)
- Landscape review completion timeline.
- Deliverable 1a machine-actionable formats discussion.
|
|
| 17 April 2024 |
6th WG Meeting: Deliverable 1b Activities
- FAIRsharing Collection standard selections.
- Discussion on ‘Defining Selection Criteria for Multi-omics Standards’.
|
|
| May 2024 |
RDA’s 22nd Virtual Plenary Meeting (VP22)
|
|
| 12 June 2024 |
7th WG Meeting: RDA VP22 Recap & Discussion
- Deliverables 1a and 1b “Next Steps”.
|
|
| 10 July 2024 |
8th WG Meeting: Invited speaker Allyson Lister
- Presentation on “How FAIRsharing Collections can help RDA WGs?”.
|
|
| 7 August 2024 |
9th WG Meeting: Deliverable 1b Activities (continued)
- Supporting materials documentation for Deliverables 1a and 1b curation workflow.
|
|
| 4 September 2024 |
10th WG Meeting: New Proposal & Scoped Activities
- RDA TIGER support services application in progress to support sustainability workflow.
|
|
| 2 October 2024 |
11th WG Meeting: Proposal Acceptance & Updates
- RDA TIGER “Call for Experts – Technical design and development for the MOMSI Landscape Dashboard”.
|
|
| 30 October 2024 |
12th WG Meeting: Collection Build & Demo Release
|
|
| 27 November 2024 |
RDA’s 23rd Plenary Meeting (P23)
|
|
| 25 December 2024 |
No Meeting: Happy Holidays! |
|
| 22 January 2025 |
13th WG Meeting: RDA TIGER Developments
- “Call for Experts” selection is complete and work has begun.
|
|
| 19 February 2025 |
14th WG Meeting: Dashboard Development Updates |
|
| 26 March 2025 |
15th WG Meeting: Dashboard Feature Highlights |
|
| 7 April 2025 |
RDA’s 24th Virtual Plenary Meeting (VP24)
|
|
| 16 April 2025 |
16th WG Meeting: Dashboard Repository Reveal & Live Demo
|
|
| 14 May 2025 |
17th WG Meeting: Dashboard in Community Review, Upcoming Activities, and IDW 2025
- Upcoming Gap Analysis Activities (final deliverable opportunties).
|
|
| 14 June 2025 |
18th WG Meeting: TBD |
|
| 14 July 2025 |
19th WG Meeting: TBD |
|
| 14 August 2025 |
20th WG Meeting: TBD |
|
| 14 September 2025 |
21st WG Meeting: TBD |
|
| 14 October 2025 |
22nd WG Meeting: TBD |
|
| 14 November 2025 |
23rd WG Meeting: TBD |
|
| December 2025 |
24th WG Meeting: TBD |
|
Note: As of August 2024, this working group’s name has changed to the “Multi-Omics Metadata Standards Integration (MOMSI) WG” and was previously known as the “RDA-OfR Creating a Multi-omics Metadata Schema Standard Reporting Matrix WG”.
The MOMSI WG are continually seeking diverse membership, representative of different countries and continents, with expertise in Omics application technologies areas of mass spectrometry and sequencing. Please reach out if you have a high interest to participate but your time zone does not align with our regularly scheduled meetings.
